Kazichene Cove (Bulgarian: залив Казичене, ‘Zaliv Kazichene’ \'za-liv ka-'zi-che-ne\) is a 2.2 km wide cove on the southeast side of Osmar Strait indenting for 1.3 km the northwest coast of Low Island in the South Shetland Islands, Antarctica. Entered between Fernandez Point and Solnik Point.
The cove is named after the settlement of Kazichene in western Bulgaria.
Kazichene Cove is located at . British mapping in 2009.
This article includes information from the Antarctic Place-names Commission of Bulgaria which is used with permission.